Just found a good app for XenDesktop,
pandion, it’s small and provide functionnality like MSN to the users.
The Pandion application does not require registry entries to function. However the Windows Installer does create a registry entry for each shortcut. These entries have no other purpose and are an artefact of the Windows Installer specification. Their value does not affect the shortcuts. The keys are created in HKEY_CURRENT_USER
So, the UPM manage user setting, and in the install you can simply point it to the %homedrive% of the user like that;
msiexec.exe /i \x.x.x.x\pandionpandion_setup.msi ALLUSERS=0 LAUNCHAPP=yes DESTINATION="U:pandion"